InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CA4

Summary

InnateDB Gene

IDBG-630241.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CA4

Gene Name

Carbonic anhydrase 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017969

Encoded Proteins

IDBP-681681

Carbonic anhydrase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167434:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:13109655-13117426

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023909

ENSBTAP00000023909

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004089	carbonate dehydratase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016829	lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0008152	metabolic process
GO:0015701	bicarbonate transport

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0031225	anchored component of membrane
GO:0031362	anchored component of external side of plasma membrane
GO:0031526	brush border membrane
GO:0046658	anchored component of plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome