InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DIABLO

Summary

InnateDB Gene

IDBG-62263.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIABLO

Gene Name

diablo, IAP-binding mitochondrial protein

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000184047

Encoded Proteins

IDBP-62265

diablo, IAP-binding mitochondrial protein

IDBP-62267

diablo, IAP-binding mitochondrial protein

IDBP-62269

diablo, IAP-binding mitochondrial protein

IDBP-384545

diablo, IAP-binding mitochondrial protein

IDBP-384547

diablo, IAP-binding mitochondrial protein

IDBP-384555

diablo, IAP-binding mitochondrial protein

IDBP-384556

diablo, IAP-binding mitochondrial protein

IDBP-585846

diablo, IAP-binding mitochondrial protein

IDBP-586125

diablo, IAP-binding mitochondrial protein

IDBP-591281

diablo, IAP-binding mitochondrial protein

IDBP-601615

diablo, IAP-binding mitochondrial protein

IDBP-585779

diablo, IAP-binding mitochondrial protein

IDBP-586465

diablo, IAP-binding mitochondrial protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:122207662-122227534

Strand

Reverse strand

Band

q24.31

Transcripts

ENST00000342392	ENSP00000339963
ENST00000267169	ENSP00000267169
ENST00000353548	ENSP00000320343
ENST00000443649	ENSP00000398495
ENST00000413918	ENSP00000411638
ENST00000439489	ENSP00000390818
ENST00000446652	ENSP00000390103
ENST00000464942	ENSP00000442360
ENST00000474004	ENSP00000442669
ENST00000489781
ENST00000485724	ENSP00000438710
ENST00000475784
ENST00000541273	ENSP00000440971
ENST00000540535	ENSP00000441139
ENST00000541656	ENSP00000440653

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	87 [view]
Protein-Protein	83 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0043065	positive regulation of apoptotic process
GO:0051402	neuron apoptotic process
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex