InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DIABLO

Summary

InnateDB Gene

IDBG-632769.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIABLO

Gene Name

diablo homolog, mitochondrial

Synonyms

SMAC

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004199

Encoded Proteins

IDBP-684422

diablo homolog, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184047:
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:55400571-55418222

Strand

Forward strand

Band

Transcripts

ENSBTAT00000005496

ENSBTAP00000005496

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0043065	positive regulation of apoptotic process
GO:0051402	neuron apoptotic process