Version 5.4
Bos taurus Gene: LGALS8
Summary
InnateDB Gene IDBG-628525.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS8
Gene Name galectin-8
Synonyms galectin-8
Species Bos taurus
Ensembl Gene ENSBTAG00000013544
Encoded Proteins
IDBP-679891
galectin-8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20154696
[Homo sapiens] LGALS8 (Gal-8), expressed in the intestinal tract, recognizes and kills human blood group antigen-expressing Escherichia coli while failing to alter the viability of other E. coli strains or other Gram-negative or Gram-positive organisms.
PMID 20208507
[Homo sapiens] LGALS8 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116977:
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:9210587-9239723
Strand Forward strand
Band
Transcripts
ENSBTAT00000018010 ENSBTAP00000018010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0002317 plasma cell differentiation
GO:0031295 T cell costimulation
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000116977
View Gene Order
ENSMUSG00000057554
View Gene Order
Cross-References
SwissProt
TrEMBL Q2YDD7
UniProt Splice Variant
Entrez Gene 506977
UniGene Bt.74256
RefSeq NM_001045954 XM_005226207 XM_005226208 XM_005226209
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110271 DAAA02061481 DAAA02061482 DAAA02061483
GenPept AAI10272
RNA Seq Atlas 506977

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca