Version 5.4
| Mus musculus Gene: Lgals8 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-130204.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Lgals8 | ||||||||
| Gene Name | lectin, galactose binding, soluble 8 | ||||||||
| Synonyms | 1200015E08Rik; AI326142; D13Ertd524e; Lgals-8 | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000057554 | ||||||||
| Encoded Proteins |
lectin, galactose binding, soluble 8
lectin, galactose binding, soluble 8
lectin, galactose binding, soluble 8
lectin, galactose binding, soluble 8
lectin, galactose binding, soluble 8
lectin, galactose binding, soluble 8
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] LGALS8 (Gal-8), expressed in the intestinal tract, recognizes and kills human blood group antigen-expressing Escherichia coli while failing to alter the viability of other E. coli strains or other
Gram-negative or Gram-positive organisms.
[Homo sapiens] LGALS8 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116977:
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 13:12439415-12464944 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | A1 | ||||||||
| Transcripts | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Mm.474138 | ||||||||
| RefSeq | NM_001199043 NM_001291055 NM_001291057 NM_001291060 NM_018886 XM_006516712 XM_006516713 XM_006516714 XM_006516715 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36592 CCDS70430 CCDS70431 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | |||||||||
| MGI Symbol | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||