Version 5.4
Bos taurus Gene: ELF1
Summary
InnateDB Gene IDBG-628643.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELF1
Gene Name ETS-related transcription factor Elf-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007356
Encoded Proteins
IDBP-680014
ETS-related transcription factor Elf-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21867680
[Homo sapiens] ELF1 transcription factor negatively regulates TOLLIP, a negative regulator of Toll-like receptor (TLR) signalling, in response to O-linked N-acetylglucosamine (O-GlcNAc) modification. In intestinal epithelial cells, insufficient O-GlcNAc modification prevents ELF1-mediated transcriptional repression and thereby suppresses TLR signalling via upregulated TOLLIP gene expression.
PMID 21867680
[Mus musculus] Elf1 transcription factor negatively regulates Tollip, a negative regulator of Toll-like receptor (TLR) signalling, in response to O-linked N-acetylglucosamine (O-GlcNAc) modification. In intestinal epithelial cells insufficient O-GlcNAc modification prevents Elf1-mediated transcriptional repression and thereby suppresses TLR signalling via upregulated Tollip gene expression. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120690:
This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:11183378-11269367
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009677 ENSBTAP00000009677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050860 negative regulation of T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120690
View Gene Order
ENSMUSG00000036461
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
ap1_pathway
AP-1 transcription factor network
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt A0JN51
TrEMBL
UniProt Splice Variant
Entrez Gene 505251
UniGene Bt.4654
RefSeq NM_001077853 XM_005213567 XM_005213568
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126517
GenPept AAI26518
RNA Seq Atlas 505251

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca