Version 5.4
Bos taurus Gene: MGC148992
Summary
InnateDB Gene IDBG-628669.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGC148992
Gene Name response gene to complement 32 protein
Synonyms C12H13orf15
Species Bos taurus
Ensembl Gene ENSBTAG00000034885
Encoded Proteins
IDBP-680040
hypothetical protein LOC614348
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102760:
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:11625778-11641053
Strand Forward strand
Band
Transcripts
ENSBTAT00000049347 ENSBTAP00000046249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030295 protein kinase activator activity
GO:0070412 R-SMAD binding
Biological Process
GO:0001100 negative regulation of exit from mitosis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0006956 complement activation
GO:0008285 negative regulation of cell proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016525 negative regulation of angiogenesis
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032967 positive regulation of collagen biosynthetic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045840 positive regulation of mitosis
GO:0050710 negative regulation of cytokine secretion
GO:0050715 positive regulation of cytokine secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051496 positive regulation of stress fiber assembly
GO:0051726 regulation of cell cycle
GO:0071158 positive regulation of cell cycle arrest
GO:0071456 cellular response to hypoxia
GO:0071850 mitotic cell cycle arrest
GO:0072537 fibroblast activation
GO:0090272 negative regulation of fibroblast growth factor production
GO:1901313 positive regulation of gene expression involved in extracellular matrix organization
GO:1901991 negative regulation of mitotic cell cycle phase transition
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000102760
View Gene Order
ENSMUSG00000022018
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL A6QLX3
UniProt Splice Variant
Entrez Gene 614348
UniGene
RefSeq NM_001102276
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148118 DAAA02032754
GenPept AAI48119
RNA Seq Atlas 614348

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca