InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NFASC

Summary

InnateDB Gene

IDBG-628670.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFASC

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000045895

Encoded Proteins

IDBP-680090

neurofascin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163531:
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:2557488-2629557

Strand

Forward strand

Band

Transcripts

ENSBTAT00000063387

ENSBTAP00000054775

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0086080	protein binding involved in heterotypic cell-cell adhesion

Biological Process

GO:0002175	protein localization to paranode region of axon
GO:0007411	axon guidance
GO:0007422	peripheral nervous system development
GO:0019226	transmission of nerve impulse
GO:0030913	paranodal junction assembly
GO:0034113	heterotypic cell-cell adhesion
GO:0042552	myelination
GO:0045162	clustering of voltage-gated sodium channels
GO:0050808	synapse organization
GO:0071205	protein localization to juxtaparanode region of axon