InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.24236

Summary

InnateDB Gene

IDBG-628726.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.24236

Gene Name

rho GTPase-activating protein 7

Synonyms

DLC-1; StARD12

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015541

Encoded Proteins

IDBP-680107

deleted in liver cancer 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164741:
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:22814893-22993901

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020664

ENSBTAP00000020664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0042169	SH2 domain binding

Biological Process

GO:0001843	neural tube closure
GO:0003007	heart morphogenesis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0021575	hindbrain morphogenesis
GO:0030036	actin cytoskeleton organization
GO:0030336	negative regulation of cell migration
GO:0030900	forebrain development
GO:0032321	positive regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0035023	regulation of Rho protein signal transduction
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035307	positive regulation of protein dephosphorylation
GO:0048041	focal adhesion assembly
GO:0051497	negative regulation of stress fiber assembly
GO:1900119	positive regulation of execution phase of apoptosis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005901	caveola
GO:0005925	focal adhesion

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000164741

View Gene Order

ENSMUSG00000031523

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

REACT_206918

Signaling by Rho GTPases pathway

REACT_210090

Rho GTPase cycle pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

rhoa_reg_pathway

Regulation of RhoA activity

Cross-References

SwissProt

TrEMBL

F1MIZ8

UniProt Splice Variant

Entrez Gene

511433

UniGene

Bt.24236

RefSeq

NM_001102493

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02060353 DAAA02060354 DAAA02060355

GenPept

RNA Seq Atlas

511433