InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ANK3

Summary

InnateDB Gene

IDBG-628851.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANK3

Gene Name

ankyrin-3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019052

Encoded Proteins

IDBP-680328

ankyrin 3, node of Ranvier (ankyrin G)

IDBP-680339

ankyrin 3, node of Ranvier (ankyrin G)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151150:
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:15818095-16073196

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061228	ENSBTAP00000053572
ENSBTAT00000025371	ENSBTAP00000025371

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0007009	plasma membrane organization
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0019228	neuronal action potential
GO:0043001	Golgi to plasma membrane protein transport
GO:0045184	establishment of protein localization
GO:0050808	synapse organization
GO:0071709	membrane assembly
GO:0072659	protein localization to plasma membrane
GO:0072660	maintenance of protein location in plasma membrane
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005923	tight junction
GO:0009925	basal plasma membrane
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0030424	axon
GO:0033268	node of Ranvier
GO:0033270	paranode region of axon
GO:0042383	sarcolemma
GO:0043194	axon initial segment
GO:0045202	synapse

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000151150

View Gene Order

ENSMUSG00000069601

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BNC9

UniProt Splice Variant

Entrez Gene

511203

UniGene

Bt.104108 Bt.104110 Bt.57467 Bt.97380

RefSeq

NM_001105620

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02061611 DAAA02061612 DAAA02061613 DAAA02061614 DAAA02061615

GenPept

RNA Seq Atlas

511203