InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HLA-DOA

Summary

InnateDB Gene

IDBG-628885.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DOA

Gene Name

HLA class II histocompatibility antigen, DO alpha chain precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006490

Encoded Proteins

IDBP-680262

major histocompatibility complex, class II, DO alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204252:
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:7218687-7220390

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008504

ENSBTAP00000008504

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0002376	immune system process
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002587	negative regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045580	regulation of T cell differentiation