Version 5.4
Bos taurus Gene: BT.64601
Summary
InnateDB Gene IDBG-628959.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.64601
Gene Name estradiol 17-beta-dehydrogenase 8
Synonyms FABGL; HKE6
Species Bos taurus
Ensembl Gene ENSBTAG00000020927
Encoded Proteins
IDBP-680350
estradiol 17-beta-dehydrogenase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204228:
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:7331889-7334005
Strand Forward strand
Band
Transcripts
ENSBTAT00000027875 ENSBTAP00000027875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0008152 metabolic process
GO:0008209 androgen metabolic process
GO:0008210 estrogen metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000204228
View Gene Order
ENSMUSG00000073422
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00140
Steroid hormone biosynthesis pathway
mmu00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MD70
UniProt Splice Variant
Entrez Gene 532422
UniGene Bt.64601
RefSeq NM_001046324
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054892
GenPept
RNA Seq Atlas 532422

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca