Version 5.4
Bos taurus Gene: NR3C2
Summary
InnateDB Gene IDBG-629327.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR3C2
Gene Name mineralocorticoid receptor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000027182
Encoded Proteins
IDBP-680729
nuclear receptor subfamily 3, group C, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151623:
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:9742222-10173282
Strand Forward strand
Band
Transcripts
ENSBTAT00000003291 ENSBTAP00000003291
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005496 steroid binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006883 cellular sodium ion homeostasis
GO:0007588 excretion
GO:0043401 steroid hormone mediated signaling pathway
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000151623
View Gene Order
ENSMUSG00000031618
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
hsa04960
Aldosterone-regulated sodium reabsorption pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.105964
RefSeq NM_001191349 XM_005217506 XM_005217507 XM_005217508
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca