Version 5.4
Bos taurus Gene: AMOTL1
Summary
InnateDB Gene IDBG-629466.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMOTL1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018945
Encoded Proteins
IDBP-680897
angiomotin like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166025:
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:15794576-15884804
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025212 ENSBTAP00000025212
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0003365 establishment of cell polarity involved in ameboidal cell migration
GO:0016055 Wnt signaling pathway
GO:0035329 hippo signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
Cellular Component
GO:0005737 cytoplasm
GO:0005923 tight junction
GO:0008180 COP9 signalosome
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000166025
View Gene Order
ENSMUSG00000013076
View Gene Order
Pathways
NETPATH
REACTOME
REACT_214353
Signal Transduction pathway
REACT_217897
Signaling by Hippo pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
REACT_196537
Signaling by Hippo pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04530
Tight junction pathway
mmu04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.56671
RefSeq XM_615060
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca