InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HHIP

Summary

InnateDB Gene

IDBG-629493.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HHIP

Gene Name

hedgehog-interacting protein precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016071

Encoded Proteins

IDBP-680906

hedgehog-interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164161:
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:13627444-13736747

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021390

ENSBTAP00000021390

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0048038	quinone binding
GO:0097108	hedgehog family protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0007405	neuroblast proliferation
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0009968	negative regulation of signal transduction
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0055114	oxidation-reduction process
GO:0060441	epithelial tube branching involved in lung morphogenesis