InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.24470

Summary

InnateDB Gene

IDBG-629632.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.24470

Gene Name

E3 ubiquitin-protein ligase TRIM37

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021677

Encoded Proteins

IDBP-681043

E3 ubiquitin-protein ligase TRIM37

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM37 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108395:
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10165557-10317934

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000035518

ENSBTAP00000035393

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0046600	negative regulation of centriole replication
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:0070842	aggresome assembly