Version 5.4
Bos taurus Gene: ELMOD2
Summary
InnateDB Gene IDBG-629686.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELMOD2
Gene Name ELMO domain-containing protein 2
Synonyms ELMOD2
Species Bos taurus
Ensembl Gene ENSBTAG00000014007
Encoded Proteins
IDBP-681106
ELMO domain-containing protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19966137
[Homo sapiens] ELMOD2 regulates the TLR3 signalling pathway where silencing of ELMOD2 in human macrophages inhibited TLR3-dependent expression of type I and type III interferon genes.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179387:
This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:17477250-17506592
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018612 ENSBTAP00000018612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0006909 phagocytosis
GO:0050688 regulation of defense response to virus
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000179387
View Gene Order
ENSMUSG00000035151
View Gene Order
Cross-References
SwissProt Q08DZ3
TrEMBL
UniProt Splice Variant
Entrez Gene 515278
UniGene Bt.105014 Bt.24332 Bt.73951 Bt.89304
RefSeq NM_001075705 XM_005217554
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123498
GenPept AAI23499
RNA Seq Atlas 515278

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca