Version 5.4
Homo sapiens Gene: ELMOD2
Summary
InnateDB Gene IDBG-38838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELMOD2
Gene Name ELMO/CED-12 domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179387
Encoded Proteins
IDBP-38840
ELMO/CED-12 domain containing 2
IDBP-811911
ELMO/CED-12 domain containing 2
IDBP-485174
ELMO/CED-12 domain containing 2
IDBP-482997
ELMO/CED-12 domain containing 2
IDBP-480952
ELMO/CED-12 domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19966137
ELMOD2 regulates the TLR3 signalling pathway where silencing of ELMOD2 in human macrophages inhibited TLR3-dependent expression of type I and type III interferon genes.
Entrez Gene
Summary This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:140524158-140553770
Strand Forward strand
Band q31.1
Transcripts
ENST00000323570 ENSP00000326342
ENST00000511887 ENSP00000476419
ENST00000507667 ENSP00000427265
ENST00000503541
ENST00000502397 ENSP00000422582
ENST00000513606 ENSP00000427592
ENST00000512057
ENST00000502290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0006909 phagocytosis
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response (InnateDB)
GO:0050688 regulation of defense response to virus
GO:0051607 defense response to virus
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035151
View Gene Order
ENSBTAG00000014007
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.450105 Hs.708494
RefSeq NM_153702 XM_005262885 XM_005262886
HUGO
OMIM
CCDS CCDS3752
HPRD 13267
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca