Version 5.4
Bos taurus Gene: SENP6
Summary
InnateDB Gene IDBG-629900.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP6
Gene Name sentrin-specific protease 6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005869
Encoded Proteins
IDBP-681325
SUMO1/sentrin specific peptidase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112701:
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:15453771-15587698
Strand Forward strand
Band
Transcripts
ENSBTAT00000007718 ENSBTAP00000007718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0016929 SUMO-specific protease activity
Biological Process
GO:0006508 proteolysis
GO:0016926 protein desumoylation
GO:0070646 protein modification by small protein removal
GO:0090169 regulation of spindle assembly
GO:0090234 regulation of kinetochore assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000112701
View Gene Order
ENSMUSG00000034252
View Gene Order
Cross-References
SwissProt
TrEMBL F1N1L7
UniProt Splice Variant
Entrez Gene 533853
UniGene Bt.77848
RefSeq NM_001192790 XM_005210672 XM_005210673
HUGO HGNC:20944
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02025278 DAAA02025279 DAAA02025280
GenPept
RNA Seq Atlas 533853

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca