Version 5.4
| Bos taurus Gene: CCNA1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-629914.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | CCNA1 | ||||||||||
| Gene Name | Uncharacterized protein | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000007284 | ||||||||||
| Encoded Proteins |
Uncharacterized protein
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133101:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 12:25129699-25140597 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Regulation of APC/C activators between G1/S and early anaphase pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
G1/S-Specific Transcription pathway
Cyclin E associated events during G1/S transition pathway
E2F mediated regulation of DNA replication pathway
G2 Phase pathway
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes pathway
Cyclin A/B1 associated events during G2/M transition pathway
DNA Replication pathway
Cellular responses to stress pathway
Synthesis of DNA pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Mitotic G2-G2/M phases pathway
Regulation of DNA replication pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
G2 Phase pathway
DNA Replication pathway
Switching of origins to a post-replicative state pathway
Cellular responses to stress pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of DNA replication pathway
Cellular Senescence pathway
Orc1 removal from chromatin pathway
Mitotic G2-G2/M phases pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Regulation of mitotic cell cycle pathway
Cyclin A/B1 associated events during G2/M transition pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Mitotic G1-G1/S phases pathway
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Cyclin E associated events during G1/S transition pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
S Phase pathway
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| KEGG |
Acute myeloid leukemia pathway
Cell cycle pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Acute myeloid leukemia pathway
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
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| INOH | |||||||||||
| PID NCI |
C-MYB transcription factor network
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| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | |||||||||||
| UniGene | Bt.10141 | ||||||||||
| RefSeq | XM_002691801 XM_005194119 XM_005194120 XM_005194121 XM_005194122 XM_005194123 XM_005194124 XM_005194125 XM_005194126 XM_005194127 XM_005194128 XM_005213732 XM_005213733 XM_005213734 XM_005213735 XM_005213736 XM_005213737 XM_005213738 XM_005213739 XM_005213740 XM_005213741 XM_600212 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | |||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | |||||||||||