Version 5.4
Mus musculus Gene: Ccna1
Summary
InnateDB Gene IDBG-145074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccna1
Gene Name cyclin A1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027793
Encoded Proteins
IDBP-145076
cyclin A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133101:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:55045469-55055055
Strand Reverse strand
Band C
Transcripts
ENSMUST00000029368 ENSMUSP00000029368
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 76 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0030154 cell differentiation
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133101
View Gene Order
ENSBTAG00000007284
Not yet available
Pathways
NETPATH
REACTOME
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_258062
Synthesis of DNA pathway
REACT_227891
G2 Phase pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188957
Cellular responses to stress pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_199110
G0 and Early G1 pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_255479
Regulation of DNA replication pathway
REACT_188820
Cellular Senescence pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_206803
Cyclin A/B1 associated events during G2/M transition pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_198608
G1/S-Specific Transcription pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_245868
Cyclin E associated events during G1/S transition pathway
REACT_220647
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_253623
S Phase pathway
KEGG
mmu05221
Acute myeloid leukemia pathway
mmu04110
Cell cycle pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_111214
G0 and Early G1 pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_1915
G2 Phase pathway
REACT_6362
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_383
DNA Replication pathway
REACT_120956
Cellular responses to stress pathway
REACT_2014
Synthesis of DNA pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_829
Regulation of DNA replication pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa04110
Cell cycle pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt Q61456
TrEMBL
UniProt Splice Variant
Entrez Gene 12427
UniGene Mm.4815
RefSeq NM_007628 XM_006500948 XM_006500949 XM_006500950 XM_006500951 XM_006500952
OMIM
CCDS CCDS17356
HPRD
IMGT
MGI ID MGI:108042
MGI Symbol Ccna1
EMBL AK077114 BC120518 BC125436 X84311
GenPept AAI20519 AAI25437 BAC36619 CAA59053
RNA Seq Atlas 12427

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca