InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: C9

Summary

InnateDB Gene

IDBG-629942.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

Complement component C9

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016149

Encoded Proteins

IDBP-681370

Complement component C9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16189651

[Homo sapiens] C9, Complement factor nine, is one of five components that interact to form the cytolytic membrane attack complex (MAC), composed of a C5B-C8 complex attached to a transmembrane C9 oligomer.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113600:
This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:35092195-35158959

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021495

ENSBTAP00000021495

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002376	immune system process
GO:0006955	immune response
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0019835	cytolysis
GO:0045087	innate immune response

Cellular Component

GO:0005576	extracellular region
GO:0005579	membrane attack complex
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle