Version 5.4
Bos taurus Gene: MCU
Summary
InnateDB Gene IDBG-629975.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCU
Gene Name calcium uniporter protein, mitochondrial precursor
Synonyms CCDC109A
Species Bos taurus
Ensembl Gene ENSBTAG00000003876
Encoded Proteins
IDBP-681424
mitochondrial calcium uniporter
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156026:
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:28868083-29061027
Strand Forward strand
Band
Transcripts
ENSBTAT00000005059 ENSBTAP00000005059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015292 uniporter activity
GO:0042802 identical protein binding
Biological Process
GO:0006851 mitochondrial calcium ion transport
GO:0019722 calcium-mediated signaling
GO:0032024 positive regulation of insulin secretion
GO:0035786 protein complex oligomerization
GO:0036444 calcium ion import into mitochondrion
GO:0042593 glucose homeostasis
GO:0051561 positive regulation of mitochondrial calcium ion concentration
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0031305 integral component of mitochondrial inner membrane
GO:0034704 calcium channel complex
GO:1990246 uniplex complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000156026
View Gene Order
ENSMUSG00000009647
View Gene Order
Cross-References
SwissProt
TrEMBL F1MDL6
UniProt Splice Variant
Entrez Gene 536656
UniGene Bt.102410
RefSeq NM_001206102
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02061870 DAAA02061871 DAAA02061872 DAAA02061873 DAAA02061874 DAAA02061875 DAAA02061876
GenPept
RNA Seq Atlas 536656

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca