Version 5.4
Bos taurus Gene: BT.45725
Summary
InnateDB Gene IDBG-630040.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.45725
Gene Name cyclin-dependent kinase 4 inhibitor B
Synonyms MTS2
Species Bos taurus
Ensembl Gene ENSBTAG00000016412
Encoded Proteins
IDBP-681476
cyclin-dependent kinase 4 inhibitor B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147883:
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22114512-22119419
Strand Forward strand
Band
Transcripts
ENSBTAT00000002652 ENSBTAP00000002652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0008285 negative regulation of cell proliferation
GO:0030219 megakaryocyte differentiation
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0031670 cellular response to nutrient
GO:0042326 negative regulation of phosphorylation
GO:0048536 spleen development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000147883
View Gene Order
ENSMUSG00000073802
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_821
Cyclin D associated events in G1 pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169274
Cellular Senescence pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_260005
G1 Phase pathway
REACT_188957
Cellular responses to stress pathway
REACT_188971
Oncogene Induced Senescence pathway
REACT_188804
Cell Cycle pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_188820
Cellular Senescence pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_250573
Mitotic G1-G1/S phases pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
mmu04350
TGF-beta signaling pathway pathway
mmu04110
Cell cycle pathway
mmu05222
Small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
INOH website
Hedgehog signaling pathway pathway
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL F1N340
UniProt Splice Variant
Entrez Gene 527124
UniGene Bt.45725
RefSeq NM_001075894
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02022236
GenPept
RNA Seq Atlas 527124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca