InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IRF8

Summary

InnateDB Gene

IDBG-630167.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF8

Gene Name

interferon regulatory factor 8

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017824

Encoded Proteins

IDBP-681610

interferon regulatory factor 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16484229

[Homo sapiens] IRF8 interacts with TRAF6 to modulate TLR signalling and may also contribute to the cross-talk between IFN-gamma and TLR signalling pathways.

PMID 18469857

[Homo sapiens] IRF8 belongs to a family of interferon (IFN) regulatory factors that modulate various important physiologic processes including host defence, cell growth and differentiation and immune regulation.

PMID 22942423

[Homo sapiens] De-SUMOylation of IRF8 at residue Lys310 acts as a molecular mechanism to trigger innate immune responses in activated macrophages. (Demonstrated in mice)

PMID 22942423

[Mus musculus] De-SUMOylation of IRF8 at residue Lys310 acts as a molecular mechanism to trigger innate immune responses in activated macrophages.

PMID 26843324

[Mus musculus] Irf8-Ifng circuit is a novel gastric innate immune mechanism in the host defense against infection with Helicobacter pylori.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140968:
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:11883376-11905043

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023694

ENSBTAP00000023694

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 316 interaction(s) predicted by orthology.

Predicted by orthology
Total	316 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006909	phagocytosis
GO:0006955	immune response
GO:0009617	response to bacterium
GO:0030099	myeloid cell differentiation
GO:0032729	positive regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0042742	defense response to bacterium
GO:0042832	defense response to protozoan
GO:0044130	negative regulation of growth of symbiont in host
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0071222	cellular response to lipopolysaccharide