Version 5.4
Homo sapiens Gene: IRF8
Summary
InnateDB Gene IDBG-45278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRF8
Gene Name interferon regulatory factor 8
Synonyms H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B; IRF-8
Species Homo sapiens
Ensembl Gene ENSG00000140968
Encoded Proteins
IDBP-45280
interferon regulatory factor 8
IDBP-745948
IDBP-752275
IDBP-750755
IDBP-746206
IDBP-752855
IDBP-747933
IDBP-745556
IDBP-749836
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16484229
IRF8 interacts with TRAF6 to modulate TLR signalling and may also contribute to the cross-talk between IFN-gamma and TLR signalling pathways.
PMID 18469857
IRF8 belongs to a family of interferon (IFN) regulatory factors that modulate various important physiologic processes including host defence, cell growth and differentiation and immune regulation.
PMID 22942423
De-SUMOylation of IRF8 at residue Lys310 acts as a molecular mechanism to trigger innate immune responses in activated macrophages. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22942423
[Mus musculus] De-SUMOylation of IRF8 at residue Lys310 acts as a molecular mechanism to trigger innate immune responses in activated macrophages.
PMID 26843324
[Mus musculus] Irf8-Ifng circuit is a novel gastric innate immune mechanism in the host defense against infection with Helicobacter pylori.
Entrez Gene
Summary Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:85898803-85922609
Strand Forward strand
Band q24.1
Transcripts
ENST00000268638 ENSP00000268638
ENST00000563180 ENSP00000458047
ENST00000564617 ENSP00000455784
ENST00000562492 ENSP00000455452
ENST00000569607 ENSP00000456395
ENST00000569145 ENSP00000455760
ENST00000564803 ENSP00000456992
ENST00000566369 ENSP00000455048
ENST00000565552 ENSP00000455816
ENST00000564056
ENST00000570088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 279 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 43 [view]
Protein-DNA 53 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 279 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006909 phagocytosis
GO:0006955 immune response
GO:0009617 response to bacterium
GO:0019221 cytokine-mediated signaling pathway
GO:0030099 myeloid cell differentiation
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041515
View Gene Order
ENSBTAG00000017824
Not yet available
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
gmcsf_pathway
GMCSF-mediated signaling events
Cross-References
SwissProt Q02556
TrEMBL H3BPS5 H3BQH6 H3BQK3 H3BRT4 H3BT31
UniProt Splice Variant
Entrez Gene 3394
UniGene Hs.137427
RefSeq NM_002163 XM_006721187
HUGO HGNC:5358
OMIM 601565
CCDS CCDS10956
HPRD 03336
IMGT
EMBL AC092723 BC126247 M91196
GenPept AAB63813 AAI26248
RNA Seq Atlas 3394

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca