Version 5.4
Bos taurus Gene: PPOX
Summary
InnateDB Gene IDBG-630178.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPOX
Gene Name protoporphyrinogen oxidase
Synonyms PPO
Species Bos taurus
Ensembl Gene ENSBTAG00000021894
Encoded Proteins
IDBP-681619
protoporphyrinogen oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143224:
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:8345630-8349334
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061124 ENSBTAP00000053328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031304 intrinsic to mitochondrial inner membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143224
View Gene Order
ENSMUSG00000062729
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9465
Heme biosynthesis pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_203298
Heme biosynthesis pathway
REACT_233360
Metabolism of porphyrins pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
INOH website
Porphyrin metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001192426 XM_005203496 XM_005203497 XM_005203498 XM_005203499
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca