Version 5.4
Bos taurus Gene: BT.24990
Summary
InnateDB Gene IDBG-630186.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.24990
Gene Name ubiquitin carboxyl-terminal hydrolase 21
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021893
Encoded Proteins
IDBP-681629
ubiquitin carboxyl-terminal hydrolase 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143258:
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:8350180-8356345
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029184 ENSBTAP00000029184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0019784 NEDD8-specific protease activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143258
View Gene Order
ENSMUSG00000053483
View Gene Order
Cross-References
SwissProt
TrEMBL F1MH36
UniProt Splice Variant
Entrez Gene 534273
UniGene Bt.24990
RefSeq NM_001046376
HUGO HGNC:12620
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006959
GenPept
RNA Seq Atlas 534273

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca