Version 5.4
Bos taurus Gene: DEDD
Summary
InnateDB Gene IDBG-630200.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEDD
Gene Name death effector domain-containing protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020154
Encoded Proteins
IDBP-681640
death effector domain-containing protein
IDBP-681643
death effector domain-containing protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158796:
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:8381806-8392000
Strand Forward strand
Band
Transcripts
ENSBTAT00000055730 ENSBTAP00000048161
ENSBTAT00000026845 ENSBTAP00000026845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0042177 negative regulation of protein catabolic process
GO:0042981 regulation of apoptotic process
GO:0046697 decidualization
GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000158796
View Gene Order
ENSMUSG00000013973
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL Q3ZCB7
UniProt Splice Variant
Entrez Gene 538428
UniGene Bt.49301
RefSeq NM_001034643 XM_005203534 XM_005203535 XM_005203536 XM_005203537 XM_005203538
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102576 DAAA02006959
GenPept AAI02577
RNA Seq Atlas 538428

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca