Version 5.4
Bos taurus Gene: BT.51616
Summary
InnateDB Gene IDBG-630238.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.51616
Gene Name ubiquitin carboxyl-terminal hydrolase 16
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020122
Encoded Proteins
IDBP-681683
ubiquitin carboxyl-terminal hydrolase 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156256:
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:6490671-6517408
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026801 ENSBTAP00000026801
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0036459 ubiquitinyl hydrolase activity
GO:0042393 histone binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0016568 chromatin modification
GO:0016578 histone deubiquitination
GO:0035522 monoubiquitinated histone H2A deubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045901 positive regulation of translational elongation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051289 protein homotetramerization
GO:0051301 cell division
GO:0070537 histone H2A K63-linked deubiquitination
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000156256
View Gene Order
ENSMUSG00000025616
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.51616
RefSeq NM_001076867 XM_005201121 XM_005201122 XM_005201123 XM_005201124 XM_005201125 XM_005201126 XM_005201127
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca