InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Usp16

Summary

InnateDB Gene

IDBG-173454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp16

Gene Name

ubiquitin specific peptidase 16

Synonyms

1200004E02Rik; 2810483I07Rik; 6330514E22Rik; UBPM

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025616

Encoded Proteins

IDBP-173456

ubiquitin specific peptidase 16

IDBP-400914

ubiquitin specific peptidase 16

IDBP-533926

ubiquitin specific peptidase 16

IDBP-541288

ubiquitin specific peptidase 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156256:
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:87454703-87483517

Strand

Forward strand

Band

C3.3

Transcripts

ENSMUST00000026710	ENSMUSP00000026710
ENSMUST00000119504	ENSMUSP00000114058
ENSMUST00000131356	ENSMUSP00000122384
ENSMUST00000144886
ENSMUST00000131206
ENSMUST00000144759	ENSMUSP00000116323
ENSMUST00000135399
ENSMUST00000146386
ENSMUST00000149656
ENSMUST00000177538
ENSMUST00000177275

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0008270	zinc ion binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042393	histone binding
GO:0043130	ubiquitin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007067	mitotic nuclear division
GO:0016578	histone deubiquitination
GO:0035522	monoubiquitinated histone H2A deubiquitination
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045901	positive regulation of translational elongation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051289	protein homotetramerization
GO:0070537	histone H2A K63-linked deubiquitination

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000156256

View Gene Order

ENSBTAG00000020122

Not yet available

Cross-References

SwissProt

TrEMBL

D3Z6E6 D6RHQ6

UniProt Splice Variant

Entrez Gene

74112

UniGene

Mm.404755

RefSeq

NM_024258 XM_006523100 XM_006523101 XM_006523102

OMIM

CCDS

CCDS28291

HPRD

IMGT

MGI ID

MGI:1921362

MGI Symbol

Usp16

EMBL

AC154631

GenPept

RNA Seq Atlas

74112