InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SMARCA1

Summary

InnateDB Gene

IDBG-630385.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCA1

Gene Name

probable global transcription activator SNF2L1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002292

Encoded Proteins

IDBP-681920

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102038:
This gene encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:13358799-13433781

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002973

ENSBTAP00000002973

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031491	nucleosome binding
GO:0036310	annealing helicase activity
GO:0070615	nucleosome-dependent ATPase activity

Biological Process

GO:0000733	DNA strand renaturation
GO:0006200	ATP catabolic process
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0007420	brain development
GO:0030182	neuron differentiation
GO:0043044	ATP-dependent chromatin remodeling
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000177	regulation of neural precursor cell proliferation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0016589	NURF complex
GO:0090537	CERF complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000102038

View Gene Order

ENSMUSG00000031099

View Gene Order

Cross-References

SwissProt

TrEMBL

F1N166

UniProt Splice Variant

Entrez Gene

535439

UniGene

RefSeq

HUGO

HGNC:11097

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02067437 DAAA02067438

GenPept

RNA Seq Atlas

535439