Version 5.4
Mus musculus Gene: Smarca1
Summary
InnateDB Gene IDBG-142130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smarca1
Gene Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Synonyms 5730494M04Rik; Snf2l
Species Mus musculus
Ensembl Gene ENSMUSG00000031099
Encoded Proteins
IDBP-142132
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
IDBP-142134
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
IDBP-142136
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
IDBP-534744
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
IDBP-715547
IDBP-539696
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102038:
This gene encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:47809368-47892974
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000077569 ENSMUSP00000076769
ENSMUST00000101616 ENSMUSP00000099138
ENSMUST00000088973 ENSMUSP00000086366
ENSMUST00000153548 ENSMUSP00000114296
ENSMUST00000141084 ENSMUSP00000135570
ENSMUST00000153587 ENSMUSP00000116209
ENSMUST00000140756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0016787 hydrolase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031491 nucleosome binding
GO:0036310 annealing helicase activity
GO:0070615 nucleosome-dependent ATPase activity
Biological Process
GO:0000733 DNA strand renaturation
GO:0006200 ATP catabolic process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007420 brain development
GO:0008152 metabolic process
GO:0030182 neuron differentiation
GO:0043044 ATP-dependent chromatin remodeling
GO:0045893 positive regulation of transcription, DNA-templated
GO:2000177 regulation of neural precursor cell proliferation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016589 NURF complex
GO:0090537 CERF complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102038
View Gene Order
ENSBTAG00000002292
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.229151 Mm.402766
RefSeq NM_001290708 NM_053123 XM_006541562 XM_006541563 XM_006541564
OMIM
CCDS CCDS30104 CCDS72374
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca