Version 5.4
Bos taurus Gene: ADK
Summary
InnateDB Gene IDBG-630619.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADK
Gene Name adenosine kinase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011072
Encoded Proteins
IDBP-682084
adenosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156110:
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:30215525-30732444
Strand Forward strand
Band
Transcripts
ENSBTAT00000014702 ENSBTAP00000014702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004001 adenosine kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006167 AMP biosynthetic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000156110
View Gene Order
ENSMUSG00000039197
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1923
Purine salvage pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
REACT_263730
Purine metabolism pathway
REACT_188937
Metabolism pathway
REACT_244050
Purine salvage pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
hsa00230
Purine metabolism pathway
mmu00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1N468
UniProt Splice Variant
Entrez Gene 783572
UniGene Bt.17456
RefSeq NM_001076066 XM_005226479
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02061908 DAAA02061909 DAAA02061910 DAAA02061911 DAAA02061912 DAAA02061913 DAAA02061914
GenPept
RNA Seq Atlas 783572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca