Version 5.4
| Bos taurus Gene: IL1R2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-630754.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | IL1R2 | ||||||||
| Gene Name | interleukin-1 receptor type 2 precursor | ||||||||
| Synonyms | IL-1R2 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000006343 | ||||||||
| Encoded Proteins |
interleukin-1 receptor type 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] IL1R2 binds to IL1A to limit post-necrotic inflammation.
[Mus musculus] Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115590:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 11:6721485-6757777 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
IL1 pathway
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| REACTOME |
Interleukin-1 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
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| KEGG |
Hematopoietic cell lineage pathway
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Amoebiasis pathway
Cytokine-cytokine receptor interaction pathway
Hematopoietic cell lineage pathway
MAPK signaling pathway pathway
Amoebiasis pathway
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| INOH |
JAK STAT pathway and regulation pathway
JAK STAT pathway and regulation pathway
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| PID NCI |
IL1-mediated signaling events
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | Q2KIE7 Q2WFX3 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 515700 | ||||||||
| UniGene | Bt.24073 | ||||||||
| RefSeq | NM_001046210 XM_005212422 XM_005212423 XM_005212424 XM_005212425 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB219098 BC112665 DAAA02030227 DAAA02030228 DAAA02030229 | ||||||||
| GenPept | AAI12666 BAE53674 | ||||||||
| RNA Seq Atlas | 515700 | ||||||||