Version 5.4
Bos taurus Gene: ANKLE2
Summary
InnateDB Gene IDBG-630842.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKLE2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000033339
Encoded Proteins
IDBP-682366
ankyrin repeat and LEM domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176915:
This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45465976-45489004
Strand Forward strand
Band
Transcripts
ENSBTAT00000000786 ENSBTAP00000000786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0007084 mitotic nuclear envelope reassembly
GO:0035307 positive regulation of protein dephosphorylation
GO:0042326 negative regulation of phosphorylation
Cellular Component
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000176915
View Gene Order
ENSMUSG00000029501
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160242
Initiation of Nuclear Envelope Reformation pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_160113
Nuclear Envelope Reassembly pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_208002
Nuclear Envelope Reassembly pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_210180
Initiation of Nuclear Envelope Reformation pathway
REACT_202512
Mitotic Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BFD1
UniProt Splice Variant
Entrez Gene 540159
UniGene Bt.26579
RefSeq XM_002694448 XM_005195003 XM_005217711 XM_591880
HUGO HGNC:29101
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02044945
GenPept
RNA Seq Atlas 540159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca