InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAD51D

Summary

InnateDB Gene

IDBG-630879.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD51D

Gene Name

DNA repair protein RAD51 homolog 4

Synonyms

RAD51L3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019082

Encoded Proteins

IDBP-682365

DNA repair protein RAD51 homolog 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185379:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:15297466-15309154

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025404

ENSBTAP00000025404

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000400	four-way junction DNA binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0042148	strand invasion

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005813	centrosome
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000185379

View Gene Order

ENSMUSG00000018841

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03440

Homologous recombination pathway

mmu03440

Homologous recombination pathway

INOH

PID NCI

Cross-References

SwissProt

Q2HJ51

TrEMBL

UniProt Splice Variant

Entrez Gene

529507

UniGene

Bt.59591

RefSeq

NM_001046304

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC113309

GenPept

AAI13310

RNA Seq Atlas

529507