Version 5.4
Bos taurus Gene: MST4
Summary
InnateDB Gene IDBG-630889.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MST4
Gene Name serine/threonine-protein kinase MST4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019652
Encoded Proteins
IDBP-682370
serine/threonine-protein kinase MST4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134602:
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:15811930-15878198
Strand Forward strand
Band
Transcripts
ENSBTAT00000026189 ENSBTAP00000026189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134602
View Gene Order
ENSMUSG00000031112
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
REACT_258521
Apoptosis pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt
TrEMBL F1N5W5
UniProt Splice Variant
Entrez Gene 539445
UniGene Bt.13435
RefSeq NM_001163786
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02067527
GenPept
RNA Seq Atlas 539445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca