InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: 2610018G03Rik

Summary

InnateDB Gene

IDBG-144889.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

2610018G03Rik

Gene Name

RIKEN cDNA 2610018G03 gene

Synonyms

2610018G03Rik; Mst4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031112

Encoded Proteins

IDBP-144891

RIKEN cDNA 2610018G03 gene

IDBP-250820

RIKEN cDNA 2610018G03 gene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134602:
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:50841047-50893097

Strand

Forward strand

Band

Transcripts

ENSMUST00000033444	ENSMUSP00000033444
ENSMUST00000114887	ENSMUSP00000110537
ENSMUST00000136741
ENSMUST00000146956

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0045595	regulation of cell differentiation

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000134602

View Gene Order

ENSBTAG00000019652

Not yet available

Pathways

NETPATH

REACTOME

REACT_258521

Apoptosis pathway

REACT_224460

Apoptotic cleavage of cellular proteins pathway

REACT_207035

Apoptotic execution phase pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_107

Apoptotic cleavage of cellular proteins pathway

REACT_995

Apoptotic execution phase pathway

REACT_578

Apoptosis pathway

KEGG

INOH

PID NCI

lkb1_pathway

LKB1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.391246 Mm.406236

RefSeq

NM_133729 XM_006541542

OMIM

CCDS

CCDS40968

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas