InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MST4

Summary

InnateDB Gene

IDBG-86408.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MST4

Gene Name

Serine/threonine-protein kinase MST4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134602

Encoded Proteins

IDBP-86416

Serine/threonine-protein kinase MST4

IDBP-241781

Serine/threonine-protein kinase MST4

IDBP-241783

Serine/threonine-protein kinase MST4

IDBP-476024

Serine/threonine-protein kinase MST4

IDBP-482707

Serine/threonine-protein kinase MST4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:132023265-132075943

Strand

Forward strand

Band

q26.2

Transcripts

ENST00000354719	ENSP00000346755
ENST00000394335	ENSP00000377868
ENST00000394334	ENSP00000377867
ENST00000481105	ENSP00000418753
ENST00000496850	ENSP00000419702

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.

Experimentally validated
Total	67 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0023014	signal transduction by phosphorylation
GO:0042981	regulation of apoptotic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031112

View Gene Order

ENSBTAG00000019652

Not yet available

Pathways

NETPATH

REACTOME

REACT_107

Apoptotic cleavage of cellular proteins pathway

REACT_995

Apoptotic execution phase pathway

REACT_578

Apoptosis pathway

KEGG

INOH

PID NCI

lkb1_pathway

LKB1 signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.444247 Hs.626479

RefSeq

NM_001042452 NM_001042453 NM_016542

HUGO

OMIM

CCDS

CCDS14631 CCDS43995 CCDS48168

HPRD

06663

IMGT

EMBL

GenPept

RNA Seq Atlas