Version 5.4
| Bos taurus Gene: CD3D | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-631274.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | CD3D | ||||||||||
| Gene Name | T-cell surface glycoprotein CD3 delta chain | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000006452 | ||||||||||
| Encoded Proteins |
T-cell surface glycoprotein CD3 delta chain
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167286:
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 15:29456451-29460605 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
PD-1 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Costimulation by the CD28 family pathway
Downstream TCR signaling pathway
Immune System pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
TCR signaling pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH |
TCR pathway
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| REACTOME |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Downstream TCR signaling pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
Phosphorylation of CD3 and TCR zeta chains pathway
PD-1 signaling pathway
Costimulation by the CD28 family pathway
TCR signaling pathway
Adaptive Immune System pathway
Immune System pathway
PD-1 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Immune System pathway
Translocation of ZAP-70 to Immunological synapse pathway
Costimulation by the CD28 family pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
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| KEGG |
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
Chagas disease (American trypanosomiasis) pathway
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
CD4 T cell receptor signaling pathway
CD4 T cell receptor signaling pathway
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| PID NCI |
TCR signaling in naïve CD8+ T cells
CXCR4-mediated signaling events
TCR signaling in naïve CD4+ T cells
Downstream signaling in naïve CD8+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
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| Cross-References | |||||||||||
| SwissProt | Q28072 | ||||||||||
| TrEMBL | V6F7N3 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 281053 | ||||||||||
| UniGene | Bt.88072 | ||||||||||
| RefSeq | NM_001034033 XM_005215797 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC102857 GJ062397 X53269 | ||||||||||
| GenPept | AAI02858 CAA37367 DAA22353 | ||||||||||
| RNA Seq Atlas | 281053 | ||||||||||