InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD3D

Summary

InnateDB Gene

IDBG-73628.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD3D

Gene Name

CD3d molecule, delta (CD3-TCR complex)

Synonyms

CD3-DELTA; IMD19; T3D

Species

Homo sapiens

Ensembl Gene

ENSG00000167286

Encoded Proteins

IDBP-73630

CD3d molecule, delta (CD3-TCR complex)

IDBP-244747

CD3d molecule, delta (CD3-TCR complex)

IDBP-588453

CD3d molecule, delta (CD3-TCR complex)

IDBP-594006

CD3d molecule, delta (CD3-TCR complex)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118338954-118342744

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000300692	ENSP00000300692
ENST00000392884	ENSP00000376622
ENST00000534687	ENSP00000434794
ENST00000529594	ENSP00000437335
ENST00000526561

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0030217	T cell differentiation
GO:0031295	T cell costimulation
GO:0045059	positive thymic T cell selection
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050776	regulation of immune response
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042101	T cell receptor complex
GO:0042105	alpha-beta T cell receptor complex