Version 5.4
Bos taurus Gene: BT.28584
Summary
InnateDB Gene IDBG-631292.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.28584
Gene Name protein canopy homolog 3 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015900
Encoded Proteins
IDBP-682818
protein canopy homolog 3 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18780723
[Homo sapiens] CNPY3 differentially interacts with TLR2, TLR4, and TLR9 and a single-nucleotide change in the CNPY3 gene can influence the strength of TLR responses and may also alter the relative activity of each TLR.
PMID 17998391
[Homo sapiens] CNPY3 (PRAT4A) is required for TLR-dependent immune responses where it regulates the subcellular distribution and response of multiple TLRs, required for both innate and adaptive immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137161:
PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression (Wakabayashi et al., 2006 [PubMed 16849487]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:16562968-16571140
Strand Forward strand
Band
Transcripts
ENSBTAT00000021132 ENSBTAP00000021132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137161
View Gene Order
ENSMUSG00000023973
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118632
Trafficking and processing of endosomal TLR pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
REACT_239142
Innate Immune System pathway
REACT_198976
Trafficking and processing of endosomal TLR pathway
REACT_230745
Immune System pathway
REACT_251547
Toll-Like Receptors Cascades pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca