InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FGF13

Summary

InnateDB Gene

IDBG-631321.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF13

Gene Name

fibroblast growth factor 13

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020194

Encoded Proteins

IDBP-682841

fibroblast growth factor 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129682:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5\' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:22043210-22118277

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000048333

ENSBTAP00000045393

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008083	growth factor activity
GO:0017080	sodium channel regulator activity
GO:0030295	protein kinase activator activity
GO:0044325	ion channel binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000165	MAPK cascade
GO:0001764	neuron migration
GO:0007026	negative regulation of microtubule depolymerization
GO:0007612	learning
GO:0007613	memory
GO:0021766	hippocampus development
GO:0021795	cerebral cortex cell migration
GO:0045200	establishment of neuroblast polarity
GO:0045860	positive regulation of protein kinase activity
GO:0046785	microtubule polymerization
GO:0048671	negative regulation of collateral sprouting
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0014704	intercalated disc
GO:0030175	filopodium
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043005	neuron projection