InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DGUOK

Summary

InnateDB Gene

IDBG-631424.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGUOK

Gene Name

deoxyguanosine kinase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012037

Encoded Proteins

IDBP-682953

deoxyguanosine kinase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114956:
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:10676630-10710886

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000047239

ENSBTAP00000044459

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004138	deoxyguanosine kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019206	nucleoside kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006468	protein phosphorylation
GO:0009165	nucleotide biosynthetic process
GO:0016310	phosphorylation
GO:0046070	dGTP metabolic process
GO:0046122	purine deoxyribonucleoside metabolic process