InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RFX3

Summary

InnateDB Gene

IDBG-631533.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFX3

Gene Name

Uncharacterized protein

Synonyms

RFX3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000819

Encoded Proteins

IDBP-683132

regulatory factor X, 3 (influences HLA class II expression)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080298:
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:41458921-41577023

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001085

ENSBTAP00000001085

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007368	determination of left/right symmetry
GO:0031018	endocrine pancreas development
GO:0042384	cilium assembly
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0050796	regulation of insulin secretion
GO:0060285	cilium-dependent cell motility
GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry
GO:0072560	type B pancreatic cell maturation
GO:2000078	positive regulation of type B pancreatic cell development

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000080298

View Gene Order

ENSMUSG00000040929

View Gene Order

Cross-References

SwissProt

TrEMBL

F1MW17

UniProt Splice Variant

Entrez Gene

538070

UniGene

Bt.63573

RefSeq

XM_002689615 XM_005209993 XM_005209994 XM_005209995 XM_005209996 XM_618263

HUGO

HGNC:9984

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02022730 DAAA02022731

GenPept

RNA Seq Atlas

538070