Version 5.4
Bos taurus Gene: KANK1
Summary
InnateDB Gene IDBG-631680.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KANK1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010976
Encoded Proteins
IDBP-683297
KN motif and ankyrin repeat domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107104:
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseuodgene has been identified on chromosome 20. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:44046426-44076904
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014571 ENSBTAP00000014571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
Biological Process
GO:0010977 negative regulation of neuron projection development
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030336 negative regulation of cell migration
GO:0030837 negative regulation of actin filament polymerization
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035413 positive regulation of catenin import into nucleus
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0090303 positive regulation of wound healing
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1900028 negative regulation of ruffle assembly
GO:2000114 regulation of establishment of cell polarity
GO:2000393 negative regulation of lamellipodium morphogenesis
Cellular Component
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000107104
View Gene Order
ENSMUSG00000032702
View Gene Order
Cross-References
SwissProt
TrEMBL F1N1B8
UniProt Splice Variant
Entrez Gene 534869
UniGene Bt.111072
RefSeq XM_002689629 XM_005199169 XM_005209997 XM_614789
HUGO HGNC:19309
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02022777 DAAA02022778
GenPept
RNA Seq Atlas 534869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca