InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NLRX1

Summary

InnateDB Gene

IDBG-631720.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRX1

Gene Name

NLR family member X1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000040569

Encoded Proteins

IDBP-683271

NLR family member X1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18311173

[Homo sapiens] NLRX1 is an amplifier of ROS generation and an inhibitor of antiviral mitochondrial signalling with markedly increased IFN-β responses in cells with down-regulated NLRX1 expression.

PMID 18200010

[Homo sapiens] NLRX1 depletion via siRNA promotes virus-induced type 1 interferon production and decreases viral replication.

PMID 18280719

[Homo sapiens] NLRX1 is an important regulator of the type I interferon (IFN) response, and prevents MAVS from signalling the activation of a type I IFN response by the RNA helicases

PMID 21703540

[Homo sapiens] NLRX1 deletion leads to constitutive interaction of MAVS and DDX58, resulting in increased inflammation. In addition to attenuating the antiviral response, NLRX1 directly associates with TRAF6 and inhibits NFkB pathway in LPS-activated macrophages.

PMID 21703539

[Homo sapiens] NLRX1 negatively regulates TLR-mediated NFkB activation by directly interacting with TRAF6 or IKK kinase. Nlrx1 knockdown in mice enhances their susceptibility to LPS-induced septic shock and increases plasma IL6 levels.

PMID 22749352

[Homo sapiens] NLRX1 attenuates type I IFN production and promotes autophagy during viral infection.

PMID 21703540

[Mus musculus] Nlrx1 deletion leads to constitutive interaction of Mavs and Ddx58, resulting in increased inflammation. Nlrx1 knockout mice showed increased expression of antiviral signalling molecules such as Ifnb, Stat2, Oas1 and Il6 after influenza infection. In addition to attenuating the antiviral response, Nlrx1 directly associates with Traf6 and inhibits NFkB pathway in LPS-activated macrophages.

PMID 21703539

[Mus musculus] Nlrx1 negatively regulates TLR-mediated NFkB activation by directly interacting with Traf6 or IKK kinase. Nlrx1 knockdown in mice enhances their susceptibility to LPS-induced septic shock and increases plasma Il6 levels.

PMID 22749352

[Mus musculus] Nlrx1 attenuates type I IFN production and promotes autophagy during viral infection. (Demonstrated in human)

PMID 24366868

[Mus musculus] Nlrx1 attenuates macrophage/microglial inflammatory activities and protects against experimental autoimmune encephalomyelitis caused by autoreactive T cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160703:
This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:30278100-30296544

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016601

ENSBTAP00000016601

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0032688	negative regulation of interferon-beta production
GO:0032715	negative regulation of interleukin-6 production
GO:0039536	negative regulation of RIG-I signaling pathway
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824	negative regulation of innate immune response
GO:0050728	negative regulation of inflammatory response