Version 5.4
Bos taurus Gene: AKTIP
Summary
InnateDB Gene IDBG-631788.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKTIP
Gene Name AKT-interacting protein
Synonyms FTS
Species Bos taurus
Ensembl Gene ENSBTAG00000016250
Encoded Proteins
IDBP-683430
AKT interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166971:
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:21926577-21937955
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021617 ENSBTAP00000021617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008152 metabolic process
GO:0008333 endosome to lysosome transport
GO:0032092 positive regulation of protein binding
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0005886 plasma membrane
GO:0030897 HOPS complex
GO:0070695 FHF complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000166971
View Gene Order
ENSMUSG00000031667
View Gene Order
Cross-References
SwissProt
TrEMBL F1N2R0
UniProt Splice Variant
Entrez Gene 540462
UniGene
RefSeq XM_005218704
HUGO HGNC:16710
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046444
GenPept
RNA Seq Atlas 540462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca