Version 5.4
Bos taurus Gene: SEMA7A
Summary
InnateDB Gene IDBG-631814.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA7A
Gene Name semaphorin-7A precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011446
Encoded Proteins
IDBP-683406
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138623:
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:34626181-34651240
Strand Forward strand
Band
Transcripts
ENSBTAT00000015210 ENSBTAP00000015210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0001934 positive regulation of protein phosphorylation
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0021988 olfactory lobe development
GO:0031175 neuron projection development
GO:0045773 positive regulation of axon extension
GO:0048675 axon extension
GO:0050727 regulation of inflammatory response
GO:0060907 positive regulation of macrophage cytokine production
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138623
View Gene Order
ENSMUSG00000038264
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
REACT_231928
Other semaphorin interactions pathway
KEGG
hsa04360
Axon guidance pathway
mmu04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BNR9
UniProt Splice Variant
Entrez Gene 614707
UniGene Bt.50081
RefSeq NM_001206185 XM_005221984
HUGO HGNC:10741
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02052504 DAAA02052505 DAAA02052506 DAAA02052507
GenPept
RNA Seq Atlas 614707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca